Centessa Pharmaceuticals plc
NASDAQ · us_market
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Centessa Pharmaceuticals plc, together with its subsidiaries, discovers, develops, and delivers orexin-based neuroscience therapeutics in the United Kingdom and the United States. The company develops ORX750, an orexin receptor 2 agonist, which is in Phase IIa clinical trial for the treatment of central disorders of hypersomnolence, including narcolepsy type 1 and 2, as well as idiopathic hypersomnia. It also engages in the development of ORX142 which is in Phase I clinical trial for the treatment of neurological and neurodegenerative disorders; ORX489 which is in Phase I clinical trial for the treatment of neuropsychiatric disorders; and LockBody, an early-stage immuno-oncology program technology platform. The company was incorporated in 2020 and is headquartered in Altrincham, the United Kingdom.
| Fund | Style | Shares | Value | % of Port | Change vs. last quarter | Period |
|---|---|---|---|---|---|---|
| FidelityFMR | fundamental | 6.85M | $272.16M | 0.01% | Trimmed-23.5% | 2026-03-31 |
| DEShaw | quant | 643.8K | $25.57M | 0.02% | Trimmed-22.6% | 2026-03-31 |
| Citadel | multi-strat | 307.4K | $12.21M | 0.02% | New | 2026-03-31 |
| RenTech | quant | 185.0K | $7.35M | 0.01% | Trimmed-33.8% | 2026-03-31 |
| TwoSigma | quant | 59.8K | $2.38M | 0.00% | Added+4.2% | 2026-03-31 |
| Report Date | EPS Estimate | EPS Actual | Surprise |
|---|---|---|---|
| 2026-08-11upcoming | -0.40 | — | — |
| 2026-05-05 | -0.41 | -0.52 | -28.08% |
| 2026-03-31 | -0.38 | -0.48 | -25.08% |
| 2025-11-05 | -0.39 | -0.41 | -4.71% |
| 2025-08-12 | -0.35 | -0.38 | -9.61% |
| 2025-05-14 | -0.28 | -0.20 | +28.57% |
| 2025-03-24 | -0.35 | -0.58 | -64.76% |
| 2024-11-12 | -0.39 | -0.37 | +4.52% |
| 2024-08-13 | -0.40 | -0.40 | -0.84% |
| 2024-05-13 | -0.40 | -0.38 | +5.00% |
| 2024-03-28 | -0.50 | -0.38 | +24.00% |
| 2023-11-13 | -0.55 | -0.40 | +27.27% |
| 2023-08-14 | -0.49 | -0.51 | -5.60% |
| 2023-05-12 | -0.41 | -0.53 | -30.33% |
| 2023-03-30 | -0.50 | -0.45 | +10.89% |
| 2022-11-10 | -0.54 | -0.57 | -5.07% |
| 30d | 90d | YTD | 1y | |
|---|---|---|---|---|
| CNTA | +0.48% | +51.76% | +58.98% | +194.30% |
| XLV | +2.97% | -4.64% | -3.44% | +12.69% |
| Alpha (stock − sector) | -2.49% | +56.39% | +62.42% | +181.61% |